It is the seco analogue of equilenin, while doisynolic acid is the seco analogue of estrone.
2.
Doisynolic acid is the parent compound of a group of synthetic, non-steroidal estrogens with high oral activity.
3.
"' Doisynolic acid "'is a synthetic, non-steroidal, orally active estrogen that was never marketed.
4.
The synthetic, non-steroidal estrogens methallenestril, fenestrel, and carbestrol were all derived from doisynolic acid and are seco analogues of the compound.
5.
The reaction of estradiol or estrone with potassium hydroxide, a strong base, results in doisynolic acid as a degradation product, which retains high estrogenic activity, and this reaction was how the drug was discovered, in the late 1930s.
6.
"' Carbestrol "'( developmental code names "'NSC-19962 "', "'ORF-2166 "') is a analogue of doisynolic acid that was described in the literature in 1956 and developed for the treatment of prostate cancer in the 1960s but was never marketed.
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